Friday, August 3, 2012

'Army of Two' returns, delves into the drug war in Mexico

1 hr.

Electronic Arts announced Thursday that, with the help of Visceral Games, it will launch a new installment in the "Army of Two" video?game franchise ??one that takes place amid the bloody drug war in Mexico.

According to EA, this third installment ? called "Army of Two: The Devil's Cartel" ? "re-sets the series" and will have a?"more intense, mature, and grittier tone." The game will be a co-operative shooter like its predecessors and is scheduled to launch for the Xbox 360 and PlayStation 3 in March 2013.

"We wanted to refresh the 'Army of Two'?franchise for a new generation of action gamers, and at the same time, stay true to the core concept that really made the first two games fan favorites,? Julian Beak, executive producer at?Visceral Games, said in a statement.?

The first games in the series were met with mediocre?reviews.?See In-Game editor Todd Kenreck's review of the second "Army of Two" game below.

But?Steve Papoutsis, general manager of Visceral Games, said their goal is "to?help improve a franchise we feel has always had a lot of potential."

Visceral Games is the development studio behind the popular "Dead Space" horror games and is currently working on "Dead Space 3." Beak said the "The Devil's Cartel" will feature "seamless co-op gameplay" as well as new tag-team features and a?deeper,?more advanced upgrade and customization system. It will be powered by the Frostbite 2 engine.

In "The Devil's Cartel," operatives Alpha and Bravo find themselves embroiled in the drug war in Mexico. And?Beak said,?"...gamers will have to work together tactically and strategically as they push through a city dominated by one of Mexico?s deadliest drug cartels."

This isn't the first time a video game has used the deadly drug war in real-world?Mexico as a backdrop. When "Call of Juarez: The Cartel" was announced it was met with much criticism?from people who felt a video?game would make light of a bloody, horrific situation that has cost thousands of people their lives. The game was then accused of being reprehensible and?racist?when it launched last year.

But the developers at Visceral Games say they are approaching "The Devil's Cartel" with the seriousness the situation ?deserves.

"The cartel wars ??the stuff that's going on in Mexico right now ? is very topical and it's also a great opportunity to shift the tone of the series a bit and really take this situation seriously," they?told?Game Informer.

Game Informer has the first video peek at this forthcoming game. Take a look:

Winda Benedetti?writes?about video?games for NBC?News. You can follow her tweets about games and other things?on Twitter?here?@WindaBenedetti?and you can?follow her?on?Google+.?Meanwhile, be sure to check?out the?IN-GAME?FACEBOOK PAGE?to discuss the day's?gaming news and reviews.

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Source: http://www.ingame.msnbc.msn.com/technology/ingame/army-two-returns-dives-drug-war-mexico-919997

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Molecular switch identified that controls key cellular process

Thursday, August 2, 2012

The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.

In a study published online this week in the Proceedings of the National Academy of Sciences, scientists at the Ludwig Institute for Cancer Research in Oxford discovered a critical molecular switch that regulates autophagy. They also studied the links between autophagy and a cellular process called senescence that stops cell growth permanently.

The researchers identified ASPP2, a tumor suppressor, as a molecular switch that can dictate the ability of a common cancer gene, known as the RAS oncogene, to either stop or promote senescence.

As Yihua Wang and researchers in Xin Lu's group at the Ludwig Institute investigated the life cycle of fibroblast cells ? the most common connective tissue cells in animals ? they found that reduced levels of the ASPP2 protein increase RAS oncogene-induced autophagic activity. This in turn prevented cells from entering senescence. Without ASPP2, the cells continued to proliferate unchecked, thereby promoting tumor growth.

ASPP2 is known to play a role in suppressing tumor development. Mice that have a deficiency or malfunction in this protein have a predisposition to developing tumors. And low ASPP2 levels in patients are linked to poor prognoses in cancers, such as large B-cell lymphomas. Reduced ASPP2 expression has also been observed in highly metastatic breast tumors. But until now, researchers did not understand why.

"We found that in the presence of the common cancer-causing RAS oncogene, ASPP2 interacted with a protein complex that is responsible for deciding cell fate via autophagy," said Yihua Wang, PhD, Ludwig researcher in Oxford.

"What this means is that the cell's emergency stop button is disabled when ASPP2 expression is reduced or lost, allowing it to proliferate unchecked as with cancer," added Wang.

"The balance between the RAS oncogene and ASPP2 activity is crucial to determining whether or not tumor growth is promoted. Our next step will be to identify ways to alter ASPP2 activity at that critical switch point. This could be an effective way to treat cancers with reduced ASPP2 expression and mutated RAS, such as breast and colon cancers," concluded Wang.

"Some of the recently developed anti-cancer drugs are potent inducers of autophagy. The new findings may also offer an explanation as to why patient response to these drugs can vary dramatically. There are factors at play within the body that can dictate authophagic activity and impact clinical outcomes," said Xin Lu, PhD, director of Ludwig's Oxford Branch. "While further study is needed, these findings may in the longer term help doctors to identify patients who are more likely to respond well to autophagic inhibition," added Lu.

###

Ludwig Institute for Cancer Research: http://www.licr.org

Thanks to Ludwig Institute for Cancer Research for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/122276/Molecular_switch_identified_that_controls_key_cellular_process_

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Thursday, August 2, 2012

Financial scandals, rigging the game and Godzilla ? Antipodean ...

Godzilla is a Japanese-originated monster character, whose main features are its incredible bulk, its melange of gorilla-like and reptilian aspects, its gargantuan appetite, and its monumentally destructive capacity. Capable of feats of enormous strength, it can defeat other mega-monsters, emitting radiation similar to that of nuclear fission thus poisoning its environs, and terrorises its enemies while leaving a path of death and destruction in its wake. It is normally represented as a towering, dinosaur-like creature, exhibiting the features of terrestrial vertebrates, and also undulating its gigantic tail similar to a crocodile. Godzilla occupies a similar place in Japanese film culture as King Kong does in Western societies; an oversized monster driven by rapacious appetites, hostility to human society and capable of causing catastrophic destruction.

Godzilla (and King Kong) occupy a niche place in the cultural world, however, there is an equivalent in the modern world. Bankzilla, the enormous, rapacious, socially destructive corporation embodied by the large banks and financial institutions, are raking in super profits while the rest of humanity, the 99 percent, are struggling with declining incomes, reduced job prospects, foreclosures and financial strain. The US Socialist Worker reported that ?To this day, Bankzilla continues to terrorize whole communities of homeowners while feasting on massive profits.? As Eric Ruder documented in this article, while the economic crisis hit the global community back in 2008-09, the large financial corporations insulated themselves from the worst of the financial disaster they had created. The cost of the ?recovery? would be shifted onto the working people. The rate of foreclosures increased, with tent cities arising in major US cities due to the unprecedented hike in mortgage defaults. But the owners of the Wall Street corporations were not complaining; they still managed to obtain super-profits while enjoying essentials such as a personal, nine-hole golf course. This was on top of the 700 billion dollar Troubled Asset Relief Programme (TARP) passed by the Democrats and Republicans in the US Congress.

What is under-reported is that the massive, taxpayer funded bailout for the ?too-big-to-fail? banks has not actually resulted in an economic recovery. If anything, lending by the big banks has actually decreased for the first three months of 2012. The CNN Finance Fortune article cited above elaborates that

?When banks cut their lending, it makes it harder for small businesses to get money to expand. But a drop in lending could also signal a drop in demand for loans, meaning businesses and individual don?t want to borrow because they are worried about the economy.?

A combined amount of 24 billion dollars was cut from lending by J P Morgan Chase, Wells Fargo, Bank of America and Citigroup in the first quarter of 2012. These are not exactly small corner stores, but enormous pillars of the finance-banking sector. The largest drops in lending were recorded in credit card loans (consumer credit) and home equity lines of credit.

The Obama administration, since coming to power in the wake of the November 2008 elections, has acted as a protector and abetter of the financial aristocracy. Not only has the previous criminality of the financial institutions not abated, but more scandals are coming to light. The Libor scandal, which involves rigging the London Interbank Exchange Rate to a level advantageous for the large banking institutions, was exposed only recently even though its antecedents date back four years. A massive case of insider trading, the Libor scandal has exposed the rotting criminality of the capitalist financial architecture.

A bank lends and borrows money ? that is understood by everyone. The acts of borrowing and lending are accompanied by interest payments. Borrowing money means that you pay interest on the loan repayment, placing savings in a bank means the saver is paid interest on those savings. How are the interest rates determined? The banking experts, given their expertise and knowledge of the world of finance, set the interest rates based on the confidence that their loans will be repaid. The cumulative knowledge of thousands of banker lenders and borrowers are analysed, supply and demand for money is assessed, and the requisite interest rate is established. Libor, the London Interbank Exchange Rate, is the average rate of interest established by the major banks in England when borrowing from other banks. The Libor serves as a benchmark for mortgages, business loans, personal loans, derivatives, credit default swaps, the interest rate on student loans ? in short, it provides a benchmark for trillions of dollars worth of loans and finance.

It turns out that the Libor was being rigged, manipulated by the major financial institutions. Starting with Barclays bank, whose top executives resigned and paid out a fine to American and British regulators, the depth of financial criminality has been steadily coming to light. Barclays chief executives defended themselves by stating that they had done nothing wrong ? because everybody was doing the same thing. The Euribor, the Brussels-based counterpart of Libor, is also being investigated for manipulation. As Petrino DiLeo explains in the Socialist Worker:

More than a dozen other banks are also being investigated for similar manipulation, including Bank of America, Citigroup, Royal Bank of Scotland Group and UBS. More fines, lawsuits and resignations may be in the offing. And there?s mounting evidence that government officials and central bankers were in on the scam, too. As the facts continue to come out, ?Liborgate? may end up being the mother of all banking scandals.

The magazine Dollars and Sense noted, when the US economy was stumbling towards the largest crisis since the great depression of the 1930s, the US administration rushed to provide bailout money through the TARP mechanism. The large privately-owned banks and financial institutions were deemed ?too-big-to-fail?. Currently, numerous state municipalities and local government authorities are facing a financial crisis because they invested in interest rate swaps. While normally borrowing on the basis of the floating exchange rate, the municipalities were offered a seemingly advantageous deal by the Wall Street giants ? interest rate swaps. State authorities ? responsible for public services and public salaries, pegged their floating-rate debt to a fixed interest rate debt agreed to by the banks. The participant with the higher interest rate had to pay the difference to their partner. While a fixed interest rate seemed like a positive development, the interest rate was set by the major banks, which was established by manipulated mechanisms, like Libor.

The municipalities have been saddled with a fixed interest rate repayment, while the floating interest rates declined in the wake of the 2008 financial crisis. The public institutions were now required to pay billions in interest repayments to the large banks, while cutting back public services and employment. These interest rate swaps are a widely used derivative device; mechanisms that were at the heart of the original financial meltdown.

The Libor scandal, growing out of the financial catastrophe of 2008, has its historic origins in an earlier measure implemented by the major imperialist powers ? bank deregulation. This was the theory that opening up banks and financial institutions to ?competition? would lead to greater choice for the individual consumer, loans with cheaper interest rates, and a healthier economic ?trickle down? of wealth. Since the mid-1980s, bank deregulation has lead to the monopolisation of the banking and finance sector by a tiny, financial aristocracy, and a transfer of wealth from the working class, the 99 percent, to the richest one percent. The chaos and financial ruin exemplified by Libor arises from an unregulated system, where actually the largest privately-owned corporations end up setting the rules by themselves. The British Bankers? Association (BBA), the main privately-controlled banking trade and lobby group, was headed by Marcus Agius. Agius was also one of the chief executives of Barclays, and heavily implicated in the Libor manipulation scandal. Agius has resigned his position, but the incestuous, nepotistic relationship between the BBA and the banking-finance sector continues.

The Guardian newspaper noted that in the 1960s and 1970s, a range of strict regulations, capital and liquidity ratios, and limits on excessive mortgage lending, were applied to the banking sector. Since the mid-1980s, as the capitalist classes around the world went on an offensive, attacking the living standards, the job provisions, health and safety regulations that provided a measure of security for workers, bank regulations were also sacrificed on the altar of the ?free-market? dogma. The Libor scandal, while correctly called the ?crime of the century?, represents more than that.

The financial scandals engulfing the financial elite of Europe and America are an indication that we are living in the era of the ?anti-1989?. In the wake of the collapse of the former socialist countries of Eastern Europe, the capitalist elites went on a triumphalist frenzy of gloating ? the socialist project seemed to have been swept away, and not just the bureaucratically deformed version of it that had obtained prior to 1989 in Eastern Europe. Francis Fukuyama, a professor of political science, enunciated the feeble ?end-of-history? thesis, arguing that ?free-market? capitalism had proven its superiority over all challenges, and ruling over societies that consented to adopt the capitalist system. Fukuyama took a Hegelian turn and conceived of the capitalist system as the final end-point, the omnipotent state to which we all aspire, much like Hegel in the nineteenth century regarded the monarchist Prussian state.

However, we are now living in the Anti-1989 era. Another nineteenth century thinker, examining the laws of motion of the capitalist system, found that the insoluble contradictions of that system would lead to its inevitable breakdown. Appropriating the same philosophical tools that Hegel used (and Fukuyama alleged borrowed), this thinker elaborated how the capitalist system works, and how it will eventually rot from within. While working class revolution is not on the immediate agenda, the current period is witnessing the re-awakening of the working class as a serious political force. The 1989 consensus that liberal capitalism is the end point of civilisation, has been reduced to ashes.

With the capitalist financial architecture crumbling, the working class, consigned to the role of passive observers in 1989, has re-emerged as a serious political force again. The 99 percent, as expressed by the Occupy Wall Street, the emergence of the Syriza socialist formation in Greece, and the eruption of popular protest throughout the Arab world, indicates that working people can no longer be sidelined by the political and economic system. Across Europe, with the mass protests in Spain, Greece and other countries, the capitalist system is declining starting with its economic periphery in Eastern Europe. Make no mistake, the current economic catastrophe began in the United States and Britain, the countries where neoliberal ?free-market? orthodoxy was applied with the strictest attention. Warnings about the dire situation ahead are emanating not just from sources routinely dismissed by the corporate-controlled media as the ?lunatic fringe? Left. Heavyweight economic analysts are also weighing in, warning that 2013 will witness further storms and stresses.

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Source: http://rupensavoulian.wordpress.com/2012/08/02/financial-scandals-rigging-the-game-and-godzilla/

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Harte-Hanks Promotes Four Individuals as Direct Marketing Company

SAN ANTONIO, TX ? (Marketwire) ? 08/01/12 ? Harte-Hanks, Inc. (NYSE: HHS), a worldwide direct and targeted marketing company that provides multichannel direct and digital marketing services and shopper advertising opportunities, announced today that it is realigning roles and responsibilities of key leaders within Harte-Hanks Direct Marketing in four areas ? customer solutions, customer strategy and engagement, customer delivery and people ? to structure the company for future growth and enhance the customer experience.

?Following the recently announced departure of Harte-Hanks Direct Marketing president Gary Skidmore, we took the opportunity to evaluate how we should position ourselves to most effectively and efficiently meet the current needs of the clients we serve while continuing to innovate for future needs in the marketplace,? said Larry Franklin, chairman & chief executive officer, Harte-Hanks. ?We have the right people for the job on our team already, so we have reorganized roles, responsibilities and business area reporting structures to position us for future growth. These changes align our leaders to better suit how client relationships and their business evolve in our company.?

Effective immediately, the leadership roles within Harte-Hanks Direct Marketing, each of whom report directly to Franklin, are as follows:

Brian Dames has been named executive vice president of customer solutions. Dames, who is already a corporate vice president, has been with the company for five years. Prior to his new role, he was responsible for leading the database and data services business of Harte-Hanks. In addition to these responsibilities, he will now oversee Trillium Software?, international operations, Aberdeen Group?, our technology market solutions, The Demand Curve?, and other business-to-business offerings. ?Brian has been a valued leader in our organization who understands that data are the currency of today?s direct marketers,? Franklin said. ?As our company has developed hugely important software and intelligence brands ? such as Trillium Software and Aberdeen ? Brian?s expertise will continue to move us forward in these key business areas, penetrating new markets while delivering innovation that seeks to build market leadership and share.?

Jeannine Falcone has been named executive vice president of customer strategy & engagement. Falcone, who is also currently a corporate vice president, has served with Harte-Hanks for close to 20 years. She currently leads The Agency Inside? and its digital solutions businesses. In addition to these responsibilities, she will assume leadership of the contact center businesses, strategy and insight team, as well as the national sales team and marketing. ?Jeannine has deep experience in all facets of multichannel marketing and customer engagement, along with a strong blend of strategic and operational focus,? Franklin said. ?Our business development efforts will remain aligned with the vertical markets of our clients, as will many of the strategies and solutions we bring to market.?

Tony Paul has been named executive vice president of customer delivery and has also been promoted to corporate vice president. Paul has been with Harte-Hanks since 2010 and has led the direct mail, mail supply chain and fulfillment businesses. He will continue his leadership of these businesses in this new organization. ?Tony has comprehensive expertise with a strong background in developing strategies, diversifying offerings and leading change,? Franklin said. ?While most marketers operate in a multichannel environment and employ integrated marketing strategies, the deep and traditional expertise of our direct mail marketing and execution of related services remains a critical function for us and our clients. Tony?s teams work closely with our other business areas, and this continued close relationship will be vital to our customer solutions and strategy teams.?

Andrew Harrison has been named executive vice president of people and has also been promoted to corporate vice president. Harrison has been with Harte-Hanks for 17 years and will continue his leadership of human resources operations, as well as working closely with the other Harte-Hanks Direct Marketing and corporate leaders on organizational transformation, change management, business performance improvement and training and professional development. ?One of the most, if not the most, important aspect of our culture and future success is people,? Franklin said. ?Andrew?s leadership in our recognition and development of people as our top asset has served to keep our company highly positioned, attractive and favored over time.?

?This organizational change reflects the caliber and depth of the leadership already in place at Harte-Hanks,? Franklin said. ?We are organized for continued innovation and excellent performance. We will work as a collaborative, integrated team to deliver a unique and compelling client experience ? while helping our clients engage and grow their customers.?

About Harte-Hanks?
Harte-Hanks? is a worldwide direct and targeted marketing company that provides multichannel direct and digital marketing services and shopper advertising opportunities to a wide range of local, regional, national and international consumer and business-to-business marketers. Harte-Hanks Direct Marketing helps its clients obtain insight about their customers through database and marketing analytics. Based on that insight Harte-Hanks Direct Marketing designs, implements and executes multichannel marketing programs on behalf of its clients using direct and digital communications. Harte-Hanks Shoppers is North America?s largest owner, operator, and distributor of shopper products which bring buyers and sellers together at a local level through its proven multichannel offerings, including targeted print, digital advertising, and classifieds. Its print publications are zoned into more than 950 separate editions and reach 11.2 million addresses each week in California and Florida. Shoppers also provide advertisers with PowerSites? to help small- and medium-size businesses establish a web presence and improve lead generation, PowerClick? SEM services, and mobile distribution of their ads and coupons. For consumers, PennySaverUSA.com? and TheFlyer.com? offer local online and mobile classifieds for garage sales, pets, used and new cars, real estate, as well as thousands of coupons and business listings. Visit us at http://www.PennySaverUSA.com, http://www.TheFlyer.com, and http://www.PowerSites.net.

This document may contain trademarks that are owned or licensed by Harte-Hanks, Inc. and its subsidiaries, including, without limitation, Harte-Hanks? and other names and marks. All other brand names, product names, or trademarks belong to their respective holders.

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Media Contact:
Morayea Pindziak
Harte-Hanks, Inc.
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Source: http://www.nearshorejournal.com/2012/08/harte-hanks-promotes-four-individuals-as-direct-marketing-company-leaders/

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You Will Have A Home Based Business: Some Terrific Suggestions ...

Most people are interested in learning how they may grow to be their own personal boss. Many people aren?t sure how to begin in their quest to get started on their own business. This informative article includes suggestions which will help you get going with your home-based business and begin working for your self, in no time whatsoever.

Include an e-mail unique introducing you home-based business. This is some thing you can have affixed immediately each and every time you mail out an e-mail. Your nearest family and friends will likely currently know about your company but all of those other folks you send emails to undoubtedly have to be advised.

Make use of the exact same advertising and marketing resources as being a normal conventional organization, to market your in the home venture. Advertising your products or services, is just as crucial, or maybe more, when you work from the residence. It is essential that the public knows how to get you and that the company exists.

Question your friends and relatives not to barge into the office, as an alternative they ought to contact you because they would should you proved helpful in the constructing elsewhere. This will likely permit you to prevent interruptions when you?re on the phone by using a consumer or focusing on some significant forms. Focusing on your business is your most important priority!

Have a large amount of fliers or leaflets composed to promote your new endeavor. There are many shops that offer quantity copying and generating for affordable amounts, usually less than 40 bucks. Mixture your brand-new fliers up around town and distribute a mailing to individuals in your town to spread the word relating to your business.

To make sure an effective home-based business, take advantage of the online to its maximum ability. The internet these days delivers extremely valuable information, resources, guides, and tips for all those commencing, operating, and advancing by using an online business. Whatever niche you lie in, using the web could possibly be your largest advantage for a way ahead for protection and success.

When operating a business in your own home, give a way for your customers to get hold of you routinely! You ought to be guaranteed to give sufficient method of get in touch with to enable them to reach you anytime. Have an answering unit for your company, fax equipment, e-mail and voicemail. When they can at the very least depart information, they will be content providing you return to them in the affordable timeframe.

If you are commencing a house enterprise, the initial thing you need to do is to take a seat, and work out how a lot it can price to completely start it. It is important to be realistic with all the expenses of your company to enable you to make certain you will be able to manage it. There are several people that hop directly into their company with out making a spending budget, and they also turn out faltering.

Many people are interested in commencing their very own online business and becoming their very own boss. Nevertheless they are not quite positive, how or in which they need to begin. After looking at this post, you should have a much better thought of how to get started off with your own home business and turning into your own personal supervisor.

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Wednesday, August 1, 2012

Klock Werks Super Saver Mufflers ? Motorcycle Parts and Tools

If you want mufflers that are affordable but certainly do not lack in quality and performance ? the Klock Werks SS Mufflers are the right fit. Big 4? slip-on mufflers with rolled-edge ends in three different designs. Constructed of all steel with flawless chrome finish. Features 2? spiral-louvered fiberglass wrapped baffles that are removable and repackable. And the sound?? Throaty rumble at idle and under acceleration which decreases to a low hum under steady cruising. Sold in pairs and PROUDLY made in the USA Available in Straight-cut, Forward slash and Back slash models. For more information on the Klock Werks Super Saver Mufflers, please visit www.kustombaggers.com

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Source: http://motorcyclepartsandtools.com/klock-werks-super-saver-mufflers/

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A &#39;Cat Whisperer&#39; Is Not The Solution For Katy Perry ? Doctor &#39;Pets&#39;

Katy Perry has been worried about the behaviour of her cats -?Kitty Purry and Krusty The Cat. They have not been behaving as usual, running away and coming for cuddles. To rectify the problem Katy has hired a ?cat whisperer?.

With all due respect to ?cat whisperers? (whatever that means), I would suggest Katy is wasting her money ? not that she has any shortage of it.

All cats hate change. As fas as a cat is concerned, the less things change the better. Change means stress, and stress results in changes of behaviour.

Now, let?s list stressful factors in Katy?s cats? lives: the split with the long time boyfriend Russell Brand, house renovations, constant travel. These things spell one thing for cats ? stress!

So how do you manage stress in cats:

  • Provide safe places. These should be quite, secluded places where a cat will not be disturbed. An upside down cardboard box works well. If the cat travels, the safe place travels with them.
  • Make time for the cat. Even if you are busy. Make sure the time you make for the cat is predictable and consistent. Even a few minutes at a time make a big difference.
  • Try Clomicalm.?Clomicalm is a synthetic cat feromone. It assists in calming a cat down. It?s not a solution to your cat-stress problems but it helps.

I suggest these simple steps could really help Katy?s cat. or your own cat if stress is a factor. And don?t waste the money on ?cat whisperers?.

Tags: cat whisperer, cats, entertainment, how to calm a stressed cat, Katy Perry, Kitty Purry, Krusty The Cat, photo, Russell Brand, stressed cats, veterinary

Dr Vadim Chelom is a Registered Veterinarian, a writer and an educator

Source: http://doctor-pets.com/2012/07/31/a-cat-whisperer-is-not-the-solution-for-katy-perry/

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